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Risks and Side Effects

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No LD50 of standard St. John’s wort extract was identified in studies of mice, rats, and dogs treated for 26 weeks, even at dosages of 5,000 mg/kg [Schulz et al., 1998, p56]. Intolerance reactions appeared at 900 mg/kg/day. No genotoxic or mutagenic effects were noted in these studies.

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